Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMilameline hydrochloride
Description: Muscarinic receptor agonist
Chemical Name: (E)-1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxaldehyde O-methyloxime hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Milameline hydrochloride
Milameline hydrochloride is a muscarinic receptor agonist that displays roughly equal affinity at all receptor subtypes (Ki values are 2.3, 2.4, 3.6, 3.8 and 4.3 μM for hM1, hM2, hM3, hM4 and hM5 receptors respectively). Cognitive enhancer; reverses spatial memory deficits in rats.
Technical Data for Milameline hydrochloride
| M. Wt | 190.67 |
| Formula | C8H14N2O.HCl |
| Storage | Desiccate at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 139886-04-7 |
| PubChem ID | 9571001 |
| InChI Key | WEBMRZODPLSRKR-MLBSPLJJSA-N |
| Smiles | CN1CC(/C=N/OC)=CCC1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Milameline hydrochloride
References for Milameline hydrochloride
References are publications that support the biological activity of the product.
Sedman et al (1995) Preclinical and phase I clinical characterization of CI-979/RU35926, a novel muscarinic agonist for the treatment of Alzheimer's disease. Life Sci. 56 877 PMID: 10188788
Wood et al (1999) Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using microphysiometry. Br.J.Pharmacol. 126 1620 PMID: 10323594
Schwarz et al (1999) Milameline (CI-979/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization. J.Pharmacol.Exp.Ther. 291 812 PMID: 10525104
View Related Products by Target
View Related Products by Product Action
Keywords: Milameline hydrochloride, Milameline hydrochloride supplier, Muscarinic, receptors, agonists, Acetylcholine, ACh, Non-selective, Muscarinics, 2604, Tocris Bioscience
Citations for Milameline hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Milameline hydrochloride.
Reviews for Milameline hydrochloride
There are currently no reviews for this product. Be the first to review Milameline hydrochloride and earn rewards!
Have you used Milameline hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.