Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMirabegron
Description: Potent and selective β3 agonist
Chemical Name: 2-Amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide
Purity: ≥98% (HPLC)
Biological Activity for Mirabegron
Mirabegron is a potent and selective β3-adrenoceptor agonist (EC50 = 22.4 nM). Displays >440-fold selectivity for β3 over β1 and β2 adrenoceptors. Increases cAMP concentration in CHO cells expressing human β3-adrenoceptor. Displays relaxant effect in ex vivo rat bladder muscle preparation precontracted with carbachol (Cat. No. 2810). Decreases frequency of bladder contraction in rats. Also promotes browning of white adipose tissue, reduces body weight, and improves glucose tolerance and insulin sensitivity in mice fed a high fat diet.
Compound Libraries for Mirabegron
Mirabegron is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Mirabegron
| M. Wt | 396.51 |
| Formula | C21H24N4O2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 223673-61-8 |
| PubChem ID | 9865528 |
| InChI Key | PBAPPPCECJKMCM-IBGZPJMESA-N |
| Smiles | NC1=NC(CC(=O)NC2=CC=C(CCNC[C@H](O)C3=CC=CC=C3)C=C2)=CS1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Mirabegron
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.65 | 100 | |
| ethanol | 7.93 | 20 |
Preparing Stock Solutions for Mirabegron
The following data is based on the product molecular weight 396.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.52 mL | 12.61 mL | 25.22 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.04 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Mirabegron
References for Mirabegron
References are publications that support the biological activity of the product.
Takasu et al (2007) Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective β3-adrenoceptor agonist, on bladder function. J.Pharmacol.Exp.Ther. 321 642 PMID: 17293563
Hao et al (2019) Beneficial metabolic effects of mirabegron in vitro and in high-fat diet-induced obese mice. J.Pharmacol.Exp.Ther. 369 419 PMID: 30940691
Sui et al (2019) Bladder drug mirabegron exacerbates atherosclerosis through activation of brown fat-mediated lipolysis. Proc.Natl.Acad.Sci.U.S.A. 116 10937 PMID: 31085638
If you know of a relevant reference for Mirabegron, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Mirabegron, Mirabegron supplier, YM178, YM, 178, potent, selective, beta3, adrenoceptor, adrenergic, receptor, agonists, agonism, bladder, relaxant, atherosclerotic, B3, Adrenergic, Beta-3, Receptors, 7070, Tocris Bioscience
Citations for Mirabegron
Citations are publications that use Tocris products.
Currently there are no citations for Mirabegron. Do you know of a great paper that uses Mirabegron from Tocris? Please let us know.
Reviews for Mirabegron
There are currently no reviews for this product. Be the first to review Mirabegron and earn rewards!
Have you used Mirabegron?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.