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Submit ReviewMiro1 Reducer
Description: Promotes mitochondrial Rho GTPase 1 (Miro1) degradation
Chemical Name: N-(3-Fluorophenyl)-N'-[4-[[6-(1H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]urea hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Miro1 Reducer
Miro1 Reducer is a promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.
Compound Libraries for Miro1 Reducer
Miro1 Reducer is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Miro1 Reducer
| M. Wt | 425.85 |
| Formula | C20H16FN7O.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2624336-91-8 |
| InChI Key | UKXRHSHXZHFFTA-UHFFFAOYSA-N |
| Smiles | FC1=CC=CC(NC(NC2=CC=C(C=C2)NC3=CC(N4C=CN=C4)=NC=N3)=O)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Miro1 Reducer
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.58 | 100 |
Preparing Stock Solutions for Miro1 Reducer
The following data is based on the product molecular weight 425.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.35 mL | 11.74 mL | 23.48 mL |
| 5 mM | 0.47 mL | 2.35 mL | 4.7 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.35 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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Product Datasheets for Miro1 Reducer
References for Miro1 Reducer
References are publications that support the biological activity of the product.
Hsieh et al (2019) Miro1 marks Parkinson's disease subset and Miro1 reducer rescues reuron ross in Parkinson's models. Cell Metab. 30 1131 PMID: 31564441
If you know of a relevant reference for Miro1 Reducer, please let us know.
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Keywords: Miro1 Reducer, Miro1 Reducer supplier, 1360287-51-9, miro1, proteasomal, degradation, reducer, reduces, mitochondrial, Rho, GTPase, 1, RHOT1, 7091, Tocris Bioscience
1 Citation for Miro1 Reducer
Citations are publications that use Tocris products. Selected citations for Miro1 Reducer include:
Manfred et al (2022) A Protumorigenic mDia2-MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts. Cancer Res 82 3701-3717 PMID: 35997559
Do you know of a great paper that uses Miro1 Reducer from Tocris? Please let us know.
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