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Submit ReviewMK 217
Description: Inhibitor of farnesyl diphosphate synthase (FPPS) and osteoclast-mediated bone resorption
Alternative Names: Alendronate sodium
Chemical Name: P,P'-(4-Amino-1-hydroxybutylidene)bis-phosphonic acid monosodium salt
Biological Activity for MK 217
Osteoclast-mediated bone resorption inhibitor. Binds and blocks farnesyl diphosphate synthase (FPPS) in the HMG-CoA pathway (IC50 = 460 nM for recombinant human FPPS); causes macrophage apoptosis. Inhibits prenylation and sterol biosynthesis in purified osteoclasts.
Technical Data for MK 217
| M. Wt | 271.08 |
| Formula | C4H12NNaO7P2 |
| Storage | Desiccate at -20°C |
| CAS Number | 129318-43-0 |
| PubChem ID | 62958 |
| InChI Key | CAKRAHQRJGUPIG-UHFFFAOYSA-M |
| Smiles | [Na+].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MK 217
References for MK 217
References are publications that support the biological activity of the product.
Bergstrom et al (2000) Alendronate is a specific, nanomolar inhibitor of fanesyl diphosphate synthase. Arch.Biochem.Biophys. 373 231 PMID: 10620343
Fournier et al (2008) Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vitro. Cancer Res. 68 8945 PMID: 18974139
Fisher et al (1999) Alendronate mechanism of action; geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc.Natl.Acad.Sci. 96 133
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Keywords: MK 217, MK 217 supplier, MK217, osteoclasts, mediated, bone, resorption, osteoporosis, inhibits, farnesyl, diphosphate, synthase, inhibitors, Alendronate, sodium, Other, Synthases/Synthetases, 4014, Tocris Bioscience
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