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Submit ReviewMK 386
Description: Potent, selective human type 1 5α-reductase inhibitor
Chemical Name: (4aR,4bS,6aR,7R,9aS,9bS,10S,11aR)-7-[(1R)-1,5-Dimethylhexyl]hexadecahydro-1,4a,6a,10-tetramethyl-2H-indeno[5,4-f]quinolin-2-one
Purity: ≥98% (HPLC)
Biological Activity for MK 386
MK 386 is a potent and selective human type 1 5α-reductase inhibitor (5αR1, IC50 = 0.9 nM). Exhibits 100-fold selectivity for 5αR1 over 5αR2 (IC50 = 154 nM). Supresses human serum and sebum dihydrotestosterone (DHT) levels in a dose-dependent manner without affecting semen DHT concentrations. Orally active.
Technical Data for MK 386
| M. Wt | 415.69 |
| Formula | C28H49NO |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 158493-17-5 |
| PubChem ID | 178013 |
| InChI Key | XUTZDXHKQDPUMA-UHFFFAOYSA-N |
| Smiles | [H][C@]1([C@@H](CCCC(C)C)C)CC[C@]2([C@@]3([C@H](C[C@]4(N(C(CC[C@@]4([C@]3(CC[C@]12C)[H])C)=O)C)[H])C)[H])[H] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MK 386
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.57 | 100 |
Preparing Stock Solutions for MK 386
The following data is based on the product molecular weight 415.69. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.03 mL | 24.06 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.81 mL |
| 10 mM | 0.24 mL | 1.2 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets for MK 386
References for MK 386
References are publications that support the biological activity of the product.
Schwartz et al (1997) MK-386, an inhibitor of 5α-reductase type 1, reduces dihydrotestosterone concentrations in serum and sebum without affecting dihydrotestosterone concentrations in semen. J.Clin.Endocrinol.Metab. 82 1373 PMID: 9141518
Bakshi et al (1994) 4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase. J.Med.Chem. 37 3871 PMID: 7966146
If you know of a relevant reference for MK 386, please let us know.
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Keywords: MK 386, MK 386 supplier, MK386, Inhibitors, inhibits, 5alpha, reductase, 5a, 5α, 5alphaR, 5aR, 5αR, type, 1, testosterone, dihydrotestosterone, DHT, steroid, hormone, Other, Reductase, Androgen, Receptor, 5842, Tocris Bioscience
Citations for MK 386
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