Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewML 204
Description: Selective TRPC4 inhibitor
Chemical Name: 4-Methyl-2-(1-piperidinyl)quinoline
Purity: ≥99% (HPLC)
Biological Activity for ML 204
ML 204 is a blocker of TRPC4 channels (IC50 values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.
Compound Libraries for ML 204
ML 204 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for ML 204
| M. Wt | 226.32 |
| Formula | C15H18N2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 5465-86-1 |
| PubChem ID | 230710 |
| InChI Key | USYRQXDHKXGTCK-UHFFFAOYSA-N |
| Smiles | CC2=CC(N3CCCCC3)=NC1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 204
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.63 | 100 | |
| 1eq. HCl | 5.66 | 25 with gentle warming |
Preparing Stock Solutions for ML 204
The following data is based on the product molecular weight 226.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.42 mL | 22.09 mL | 44.19 mL |
| 5 mM | 0.88 mL | 4.42 mL | 8.84 mL |
| 10 mM | 0.44 mL | 2.21 mL | 4.42 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.88 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for ML 204
References for ML 204
References are publications that support the biological activity of the product.
Miller et al (2011) Novel chemical inhibitor of TRPC4 channels. Probe Reports from the Molecular Libraries Program PMID: 22049577
Miller et al (2011) Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/5 ion channels. J.Biol.Chem. 286 33436 PMID: 21795696
If you know of a relevant reference for ML 204, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ML 204, ML 204 supplier, ML204, TRPC4, blockers, transient, receptor, potential, channels, canonical, TRPC, 4732, Tocris Bioscience
1 Citation for ML 204
Citations are publications that use Tocris products. Selected citations for ML 204 include:
Gertjan et al (2021) Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels. PLoS Biol 19 e3001070 PMID: 33481771
Do you know of a great paper that uses ML 204 from Tocris? Please let us know.
Reviews for ML 204
There are currently no reviews for this product. Be the first to review ML 204 and earn rewards!
Have you used ML 204?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image