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Submit ReviewML 289
Discontinued Product
4976 has been discontinued.
View all Glutamate (Metabotropic) Group II Receptors products.
Description: Selective negative allosteric modulator of mGlu3 receptors
Chemical Name: [(3R)-3-(Hydroxymethyl)-1-pipridinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]methanone
Purity: ≥98% (HPLC)
Biological Activity for ML 289
ML 289 is a selective negative allosteric modulator at mGlu3 receptors (IC50 = 660 nM). Exhibits 15-fold selectivity for mGlu3 over mGlu2. Centrally penetrant.
Technical Data for ML 289
| M. Wt | 349.42 |
| Formula | C22H23NO3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1382481-79-9 |
| PubChem ID | 56587994 |
| InChI Key | VSLWUPHHCFQTDB-LJQANCHMSA-N |
| Smiles | O=C(N3CCC[C@@H](CO)C3)C(C=C2)=CC=C2C#CC1=CC=C(OC)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ML 289
References for ML 289
References are publications that support the biological activity of the product.
Sheffler et al (2012) Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg.Med.Chem.Lett. 22 3921 PMID: 22607673
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Keywords: ML 289, ML 289 supplier, ML289, selective, allosteric, modulators, mglu3, mglu_3, metabotropic, glutamate, receptors, NAMs, group, II, 2, Glutamate, (Metabotropic), Group, Receptors, 4976, Tocris Bioscience
Citations for ML 289
Citations are publications that use Tocris products.
Currently there are no citations for ML 289.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.