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Submit ReviewML 298 hydrochloride
Description: Selective PLD2 inhibitor
Chemical Name: 3,4-Difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]benzamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for ML 298 hydrochloride
ML 298 hydrochloride is a selective inhibitor of phospholipase D2 (PLD2) (IC50 values are 355 and >20,000 nM for PLD2 and PLD1, respectively). Decreases invasive migration in U87-MG glioblastoma cells, without affecting cell viability.
Technical Data for ML 298 hydrochloride
| M. Wt | 468.9 |
| Formula | C22H23F3N4O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| PubChem ID | 78243721 |
| InChI Key | GMGMJMDCWRCPHP-UHFFFAOYSA-N |
| Smiles | O=C(NCCN2CCC(C(NCN3C4=CC(F)=CC=C4)=O)3CC2)C1=CC=C(F)C(F)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ML 298 hydrochloride
References for ML 298 hydrochloride
References are publications that support the biological activity of the product.
O'Reilly et al (2013) Development of dual PLD1/2 adn PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. J.Med.Chem. 56 2695 PMID: 23445448
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Keywords: ML 298 hydrochloride, ML 298 hydrochloride supplier, ML298, hydrochloride, PLD2, phospholipase, 2, inhibitors, inhibits, selective, Phospholipases, 4895, Tocris Bioscience
1 Citation for ML 298 hydrochloride
Citations are publications that use Tocris products. Selected citations for ML 298 hydrochloride include:
Hartlerode et al (2015) Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors. Nat Struct Mol Biol 22 736 PMID: 26280532
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