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Description: Selective negative allosteric modulator of mGlu3 receptors
Chemical Name: [2-Fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone
Purity: ≥98% (HPLC)
Biological Activity for ML 337
ML 337 is a selective negative allosteric modulator of mGlu3 (IC50 = 593 nM). Displays no activity at mGlu1, mGlu2 or mGlu4-8 at concentrations up to 30 μM. Brain penetrant.
Compound Libraries for ML 337
ML 337 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for ML 337
| M. Wt | 353.39 |
| Formula | C21H20FNO3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1443118-44-2 |
| PubChem ID | 60204017 |
| InChI Key | QBCRLDPMQHPGIM-QGZVFWFLSA-N |
| Smiles | O=C(N1CCC[C@@H](O)C1)C(C(F)=C2)=CC=C2C#CC3=CC=C(OC)C=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 337
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.34 | 100 | |
| ethanol | 7.07 | 20 |
Preparing Stock Solutions for ML 337
The following data is based on the product molecular weight 353.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.83 mL | 14.15 mL | 28.3 mL |
| 5 mM | 0.57 mL | 2.83 mL | 5.66 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.83 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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Product Datasheets for ML 337
References for ML 337
References are publications that support the biological activity of the product.
Wenthur et al (2013) Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM). J.Med.Chem. 56 5208 PMID: 23718281
If you know of a relevant reference for ML 337, please let us know.
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Keywords: ML 337, ML 337 supplier, ML337, mglu, metabotropic, glutamate, mGlu3, receptors, negative, allosteric, modulators, NAMs, selective, Glutamate, (Metabotropic), Group, II, Receptors, 4982, Tocris Bioscience
Citations for ML 337
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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