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Submit ReviewML 352 hydrochloride
Description: High affinity and selective presynaptic choline transporter (CHT) inhibitor
Chemical Name: 4-Methoxy-N-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-3-[(1-methyl-4-piperidinyl)oxy]benzamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for ML 352 hydrochloride
High affinity and selective presynaptic choline transporter (CHT) inhibitor (Ki = 92 nM). Exhibits selectivity for CHT over dopamine, serotonin and noradrenalin transporters; acetylcholinesterase and cholineacetyltransferase; and a panel of 65 other GPCRs, ion channels and transporters.
Technical Data for ML 352 hydrochloride
| M. Wt | 423.93 |
| Formula | C21H29N3O4.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1962928-20-6 |
| PubChem ID | 121513888 |
| InChI Key | UKLCTDBUTADGBD-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C(NCC3=CC(C(C)C)=NO3)=O)C=C1OC2CCN(C)CC2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ML 352 hydrochloride
References for ML 352 hydrochloride
References are publications that support the biological activity of the product.
Ennis et al (2015) Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter. ACS Chem.Neurosci. 6 417 PMID: 25560927
Bollinger et al (2015) Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter. Bioorg.Med.Chem.Lett. 25 1757 PMID: 25801932
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.