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Submit ReviewML 354
Description: Selective PAR4 antagonist
Chemical Name: 1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol
Purity: ≥98% (HPLC)
Biological Activity for ML 354
ML 354 is a selective PAR4 antagonist (IC50 = 140 nM). Exhibits 70-fold selectivity for PAR4 over PAR1.
Technical Data for ML 354
| M. Wt | 282.29 |
| Formula | C16H14N2O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 89159-60-4 |
| PubChem ID | 752812 |
| InChI Key | GNJUKVGDCUKDLF-UHFFFAOYSA-N |
| Smiles | CN2C1=CC=C([N+]([O-])=O)C=C1C(C3=CC=CC=C3)=C2CO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ML 354
References for ML 354
References are publications that support the biological activity of the product.
Wen et al (2014) Substituted indoles as selective protease activated receptor 4 (PAR4) antagonists: Discovery and SAR of ML354. Bioorg.Med.Chem.Lett. 24 4708 PMID: 25176330
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Keywords: ML 354, ML 354 supplier, ML354, SID161004646, VU0099704, selective, protease, activated, receptors, PAR4, antagonists, Protease-Activated, Receptors, 5387, Tocris Bioscience
1 Citation for ML 354
Citations are publications that use Tocris products. Selected citations for ML 354 include:
Sébert et al (2018) Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease-activated receptor 1- and protease-activated receptor 4-dependent mechanism. Br J Pharmacol 175 3656 PMID: 29959891
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