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Submit ReviewMNI caged kainic acid
Description: Caged kainic acid
Chemical Name: (2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid 4-methoxy-7-nitro-1H-indolinyl amide
Purity: ≥99% (HPLC)
Biological Activity for MNI caged kainic acid
Kainic acid (Cat.No. 0222) caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Generates large inward currents at resting membrane potential upon wide field photolysis in Purkinje neurons. Selectively photoactivates kainate receptors when used in conjunction with an AMPA antagonist, such as GYKI 53655 (Cat.No. 2555). Suitable for uncaging with 300-380 nm excitation. Exhibits rapid uncaging rate relative to ionotropic glutamate receptor activation. Also suitable for two-photon uncaging experiments at 720 nm.
Licensing Information
Sold under licence from the Medical Research Council
Technical Data for MNI caged kainic acid
| M. Wt | 389.4 |
| Formula | C19H23N3O6 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1315378-75-6 |
| PubChem ID | 57414719 |
| InChI Key | IQGCUMUIYXHZOT-AHIWAGSCSA-N |
| Smiles | C=[C@@](C)[C@@H]1[C@H](CC(N2C(C([N+]([O-])=O)=CC=C3OC)=C3CC2)=O)[C@@H]([C@](O)=O)NC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MNI caged kainic acid
References for MNI caged kainic acid
References are publications that support the biological activity of the product.
Maier et al (2005) Comparative analysis of inhibitor effects of caged ligands for the NMDA receptor. J.Neurosci.Meths. 142 1 PMID: 15652611
Palma-Cerda et al (2013) New caged neurotransmitter analogues based on methoxy-nitroindole and nitrophenylethoxycarbonyl caging groups are selective for glutamate receptor subtypes. Neuropharmacology 63 624 PMID: 22609535
Palma-Cerda et al (2012) New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups. Neuropharmacology. 63 624 PMID: 22609535
Passlick and Ellis-Davies et al (2017) Comparative one- and two-photon uncaging of MNI-glutamate and MNI-kainate on hippocampal CA1 neurons. J.Neurosci.Methods. PMID: 29051090
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1 Citation for MNI caged kainic acid
Citations are publications that use Tocris products. Selected citations for MNI caged kainic acid include:
Passlick and Ellis-Davies (2017) Comparative one- and two-photon uncaging of MNI-glutamate and MNI-kainate on hippocampal CA1 neurons. J.Neurosci.Methods. 293 321 PMID: 29051090
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Metabotropic Glutamate Receptors Scientific Review
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