Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMO-I-500
Description: FTO inhibitor; anticonvulsant
Chemical Name: N-[5-(4-Chlorophenyl)-3,4-dihydroxy-2-furanyl]ethanesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for MO-I-500
MO-I-500 is a FTO inhibitor (IC50 = 8.7 μM for purified FTO in vitro), which increases N6-methyladenosine (m6A) levels in total cellular mRNA in HeLa cells. MO-I-500 modulates levels of specific miRNAs. In a triple-negative breast cancer cell line metabolically challenged by culture without glutamine (SUM149-MA cells), MO-I-500 inhibits cell proliferation. MO-I-500 also displays anticonvulsant activity in a 6 Hz mouse model of epilepsy at nontoxic doses.
Compound Libraries for MO-I-500
MO-I-500 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for MO-I-500
| M. Wt | 317.75 |
| Formula | C12H12ClNO5S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1585219-04-0 |
| PubChem ID | 73505416 |
| InChI Key | WWHUSZQHRUNRSB-UHFFFAOYSA-N |
| Smiles | CCS(=O)(NC1=C(C(O)=C(C2=CC=C(C=C2)Cl)O1)O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MO-I-500
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.77 | 100 |
Preparing Stock Solutions for MO-I-500
The following data is based on the product molecular weight 317.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.15 mL | 15.74 mL | 31.47 mL |
| 5 mM | 0.63 mL | 3.15 mL | 6.29 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.15 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for MO-I-500
References for MO-I-500
References are publications that support the biological activity of the product.
Zheng et al (2014) Synthesis of a FTO inhibitor with anticonvulsant activity. ACS.Chem.Neurosci. 5 658 PMID: 24834807
Singh et al (2016) Important role of FTO in the survival of rare panresistant triple-negative inflammatory breast cancer cells facing a severe metabolic challenge. PLoS One. 11 PMID: 27390851
If you know of a relevant reference for MO-I-500, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: MO-I-500, MO-I-500 supplier, FTO, inhibitors, inhibits, anticonvulsant, mRNA, N6-methyladenine, demethylase, α, alfa, alpha-ketoglutarate-dependent, dioxygenase, fat, mass, and, obesity-associated, protein, Other, Oxygenases/Oxidases, 6871, Tocris Bioscience
Citations for MO-I-500
Citations are publications that use Tocris products.
Currently there are no citations for MO-I-500. Do you know of a great paper that uses MO-I-500 from Tocris? Please let us know.
Reviews for MO-I-500
There are currently no reviews for this product. Be the first to review MO-I-500 and earn rewards!
Have you used MO-I-500?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image