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Submit ReviewMorphine hydrochloride
Description: Narcotic opioid analgesic
Chemical Name: 7,8-Didehydro-4,5-epoxy-17-methyl-(5α,6α)-morphinan-3,6-diol hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Morphine hydrochloride
Morphine hydrochloride is a narcotic opioid analgesic.
Technical Data for Morphine hydrochloride
| M. Wt | 321.8 |
| Formula | C17H19NO3.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 52-26-6 |
| PubChem ID | 5464110 |
| InChI Key | XCKKIKBIPZJUET-VYKNHSEDSA-N |
| Smiles | O[C@@H]3[C@H]5[C@]24C1=C(O5)C(O)=CC=C1C[C@@H](N(C)CC4)[C@@]([H])2C=C3.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Morphine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 16.09 | 50 |
Preparing Stock Solutions for Morphine hydrochloride
The following data is based on the product molecular weight 321.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.22 mL | 31.08 mL | 62.15 mL |
| 2.5 mM | 1.24 mL | 6.22 mL | 12.43 mL |
| 5 mM | 0.62 mL | 3.11 mL | 6.22 mL |
| 25 mM | 0.12 mL | 0.62 mL | 1.24 mL |
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Product Datasheets for Morphine hydrochloride
References for Morphine hydrochloride
References are publications that support the biological activity of the product.
Merck Index 12 1074
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Keywords: Morphine hydrochloride, Morphine hydrochloride supplier, opioid, receptors, analgesic, Miscellaneous/Non-selective, Opioids, 5158, Tocris Bioscience
4 Citations for Morphine hydrochloride
Citations are publications that use Tocris products. Selected citations for Morphine hydrochloride include:
Prather et al (2013) CB1 and CB2 receptors are novel molecular targets for tamox. and 4OH-Tamoxifen. Biochem Biophys Res Commun 441 339 PMID: 24148245
Rajasekaran et al (2013) Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors. Toxicol Appl Pharmacol 269 100 PMID: 23537664
Mohammad et al (2021) Effects of intrathecal and intracerebroventricular microinjection of kaempferol on pain: possible mechanisms of action. Res Pharm Sci 16 203-216 PMID: 34084207
Jose A et al (2021) An endogenous opioid circuit determines state-dependent reward consumption. Nature 598 646-651 PMID: 34646022
Do you know of a great paper that uses Morphine hydrochloride from Tocris? Please let us know.
Reviews for Morphine hydrochloride
Average Rating: 5 (Based on 1 Review.)
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Morphine inhibits AITC-induced p42/44 phosphorylation in brain.
By
Christopher Trummer on 10/15/2018
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: Brain
Saline or morphine (10 mg/kg, s.c.) was injected 1 h prior to intrarectal instillation of peanut oil (Veh) or AITC 2% (v/v) in mice. Phosphorylation of p42/44 was analysed in spinal cord (Sc), thalamus (Th), hypothalamus (Hth), amygdala (Amy), and prefrontal cortex (Pfc) lysates using Western blot. Morphine significantly inhibited AITC-induced pp42/44 expression (shown in Image).
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