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Submit ReviewMRS 2957 triethylammonium salt
Description: Potent and selective P2Y6 agonist
Chemical Name: P1-[5'(N4-Methoxycytidyl)]-P3-(5'-uridyl)-triphosphate tri(triethylammonium) salt
Purity: ≥99% (HPLC)
Biological Activity for MRS 2957 triethylammonium salt
MRS 2957 triethylammonium salt is a potent P2Y6 agonist (EC50 = 12 nM). Displays 14- and 66-fold selectivity against P2Y2 and P2Y4 receptors respectively.
Technical Data for MRS 2957 triethylammonium salt
| M. Wt | 1042.94 |
| Formula | C19H28N5O20P3.3(C2H5)3N |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| PubChem ID | 90488923 |
| InChI Key | UCQYWKBGVXRIQK-BJFMRLMLSA-N |
| Smiles | O[C@@H]1[C@@H](N2C(NC(C=C2)=O)=O)O[C@@H](COP(OP(OP(OC[C@H]3O[C@@H](N4C(NC(C=C4)=NOC)=O)[C@H](O)[C@@H]3O)([O-])=O)([O-])=O)([O-])=O)[C@@H]1O.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MRS 2957 triethylammonium salt
References for MRS 2957 triethylammonium salt
References are publications that support the biological activity of the product.
Maruoka et al (2010) Pyrimidine ribonucleotides with enhanced selectivity as P2Y6 receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate γ-ester modifications. J.Med.Chem. 53 4488 PMID: 20446735
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1 Citation for MRS 2957 triethylammonium salt
Citations are publications that use Tocris products. Selected citations for MRS 2957 triethylammonium salt include:
Balasubramanian et al (2014) Enhancement of glucose uptake in mouse skeletal muscle cells and adipocytes by P2Y6 receptor agonists. Nat Methods 9 e116203 PMID: 25549240
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.