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MS 39N

Cat. No. 7398 Submit a Review Datasheet / COA / SDS
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Description: Negative control for MS 39 (Cat. No. 7397)
Chemical Name: (2R,4S)-1-((S)-2-(11-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-11-oxoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for MS 39N

MS 39N is a negative control for MS 39 (Cat. No. 7397). Binds EGFR without inducing degradation.

Licensing Information

Sold under license from Icahn School of Medicine at Mount Sinai.

Technical Data for MS 39N

M. Wt 1056.74
Formula C55H71ClFN9O7S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2675490-96-5
PubChem ID 155565089
InChI Key HLFLODKZIGYHNR-YFXVFWABSA-N
Smiles COC1=CC2=NC=NC(NC3=CC(Cl)=C(C=C3)F)=C2C=C1OCCCN4CCN(CC4)C(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](C[C@@H]5C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MS 39N

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 105.67 100

Preparing Stock Solutions for MS 39N

The following data is based on the product molecular weight 1056.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.95 mL 4.73 mL 9.46 mL
5 mM 0.19 mL 0.95 mL 1.89 mL
10 mM 0.09 mL 0.47 mL 0.95 mL
50 mM 0.02 mL 0.09 mL 0.19 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References for MS 39N

References are publications that support the biological activity of the product.

Cheng et al (2020) Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders. J.Med.Chem. 63 1216 PMID: 31895569

If you know of a relevant reference for MS 39N, please let us know.

View Related Products by Target

Keywords: MS 39N, MS 39N supplier, MS39N, Negative, controls, PROTAC, PROTACs, degraders, degrades, MS39, MS, 39, EGFRs, proteolysis-targeting, chimera, EGFR, Controls, 7398, Tocris Bioscience

Citations for MS 39N

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

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  • Degrader Building Blocks
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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia