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Description: Specific group III mGlu antagonist
Chemical Name: (RS)-α-Methylserine-O-phosphate
Biological Activity for MSOP
MSOP is a selective group III metabotropic glutamate receptor antagonist. Displays an apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Has no activity on postsynaptic mGlu receptors or on ionotropic glutamate receptors on neonatal rat motoneurons.
Technical Data for MSOP
| M. Wt | 199.1 |
| Formula | C4H10NO6P |
| Storage | Store at RT |
| CAS Number | 66515-29-5 |
| PubChem ID | 3964633 |
| InChI Key | GSFCOAGADOGIGE-UHFFFAOYSA-N |
| Smiles | NC(COP(O)(O)=O)(C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MSOP
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 19.91 | 100 |
Preparing Stock Solutions for MSOP
The following data is based on the product molecular weight 199.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.02 mL | 25.11 mL | 50.23 mL |
| 5 mM | 1 mL | 5.02 mL | 10.05 mL |
| 10 mM | 0.5 mL | 2.51 mL | 5.02 mL |
| 50 mM | 0.1 mL | 0.5 mL | 1 mL |
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Product Datasheets for MSOP
References for MSOP
References are publications that support the biological activity of the product.
Thomas et al (1996) α-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists. Neuropharmacology 35 637 PMID: 8887973
Jane et al (1996) Phosphono substituted amino acids as selective metabotropic glutamate receptor antagonists. Phosphorous, Sulphur and Silicon 109-110 313
Thomas et al (1995) Serine-O-phosphate derivatives as novel, potent and selective metabotropic glutamate receptor (mGluR) antagonists. Soc.Neurosci.Abstr. 21 P616
If you know of a relevant reference for MSOP, please let us know.
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View all Glutamate (Metabotropic) Group III Receptor Antagonists
Keywords: MSOP, MSOP supplier, Specific, group, III, mGlur, antagonists, Group, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, (Metabotropic), 0803, Tocris Bioscience
7 Citations for MSOP
Citations are publications that use Tocris products. Selected citations for MSOP include:
Spaziano et al (2015) Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. Proc Natl Acad Sci U S A 2015 980983 PMID: 25866824
Liu et al (2013) Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings. J Neurophysiol 110 505 PMID: 23636718
Ster et al (2011) Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors. J Neurosci 108 9993 PMID: 21628565
Melyan et al (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci 24 4530 PMID: 15140923
Derbenev et al (2006) Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus. J Physiol 26 9666 PMID: 16988037
Browning et al (2006) Vagal afferent control of opioidergic effects in rat brainstem circuits. Biomed Res Int 575 761 PMID: 16825311
Jiang et al (2006) Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism. J Neurosci 26 4318 PMID: 16624952
Do you know of a great paper that uses MSOP from Tocris? Please let us know.
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Literature in this Area
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Metabotropic Glutamate Receptors Scientific Review
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