Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMU 1700 trihydrochloride New
Description: Potent and selective ALK1/2 inhibitor. Brain-penetrant
Chemical Name: 6-(4-Piperazin-1-ylphenyl)-3-quinolin-4-ylfuro[3,2-b]pyridine trihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for MU 1700 trihydrochloride
MU 1700 trihydrochloride is a potent and selective ALK2 and ALK1 inhibitor (IC50 values are 6 nM and 13 nM, respectively in biochemical assays). It is also a potent ALK6 inhibitor (IC50 = 41 nM). It shows selectivity for ALK over >360 other kinases. It shows favorable pharmacokinetic for in vivo use. MU 1700 trihydrochloride is orally bioavailable. It is cell membrane permeable and brain penetrant.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MU 1700 probe summary on the SGC website.
Technical Data for MU 1700 trihydrochloride
| M. Wt | 515.86 |
| Formula | C26H22N4O.3HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| InChI Key | RRVVHPUANQAUJY-UHFFFAOYSA-N |
| Smiles | C12=C(C=CC=C2)N=CC=C1C3=COC4=C3N=CC(C5=CC=C(C=C5)N6CCNCC6)=C4.Cl.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MU 1700 trihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.16 | 10 | |
| water | 25.79 | 50 |
Preparing Stock Solutions for MU 1700 trihydrochloride
The following data is based on the product molecular weight 515.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.88 mL | 19.39 mL | 38.77 mL |
| 2.5 mM | 0.78 mL | 3.88 mL | 7.75 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.88 mL |
| 25 mM | 0.08 mL | 0.39 mL | 0.78 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for MU 1700 trihydrochloride
References for MU 1700 trihydrochloride
References are publications that support the biological activity of the product.
Němec et al (2024) Discovery of two highly selective structurally orthogonal chemical probes for activin receptor-like kinases 1 and 2. J.Med.Chem. 67 12632 PMID: 39023313
If you know of a relevant reference for MU 1700 trihydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: MU 1700 trihydrochloride, MU 1700 trihydrochloride supplier, MU1700, 3HCl, MU-1700, potent, selective, alk, inhibitors, inhibits, kinases, tyrosine, kinase, 2, ALK, ALK1, ALK2, ALK6, orally, bioavailable, brain, penetrant, in, vivo, 8832, Tocris Bioscience
Citations for MU 1700 trihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for MU 1700 trihydrochloride. Do you know of a great paper that uses MU 1700 trihydrochloride from Tocris? Please let us know.
Reviews for MU 1700 trihydrochloride
There are currently no reviews for this product. Be the first to review MU 1700 trihydrochloride and earn rewards!
Have you used MU 1700 trihydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image