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Submit ReviewN-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide
Description: Nitroxyl precursor
Biological Activity
A pro-drug of the potent vasorelaxant nitroxyl, H-N=O, which it slowly releases in neutral solution. HNO eventually dimerizes and dehydrates to N2O, without producing NO. Also a powerful inhibitor of aldehyde dehydrogenase.
Technical Data
| M. Wt | 291.71 |
| Formula | C10H10ClNO5S |
| Storage | Desiccate at +4°C |
| CAS Number | 142867-52-5 |
| PubChem ID | 688598 |
| InChI Key | GWYBSWWLKXEDLB-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(S(N(C(C)=O)OC(C)=O)(=O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Fukuto et al (1992) N,O-Diacylated-N-hydroxyarylsulfonamides: nitroxyl precursors with potent smooth muscle relaxant properties. Biochem.Biophys.Res.Commun. 187 1367 PMID: 1417812
Lee et al (1992) Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase. J.Med.Chem. 35 3648 PMID: 1433175
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Keywords: N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide, N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide supplier, Nitroxyl, precursor, ROS, Donors, NO, Precursors, Nitric, Oxide, Signaling, Signalling, /, 0722, Tocris Bioscience
Citations for N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide
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