Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewNα-Methylhistamine dihydrochloride
Discontinued Product
0573 has been discontinued.
View all Histamine H<sub>3</sub> Receptors products.
Description: Non-selective H3 agonist
Chemical Name: N-Methyl-1H-imidazole-4-ethanamine dihydrochloride
Biological Activity for Nα-Methylhistamine dihydrochloride
Nα-Methylhistamine dihydrochloride is a potent histamine agonist, particularly at H3 receptors (potency relative to histamine is 81, 185, and 270% at H1, H2 and H3 respectively). Also displays agonist properties at H4 receptors to which it binds with moderate affinity (Ki = 23 nM).
Technical Data for Nα-Methylhistamine dihydrochloride
| M. Wt | 198.09 |
| Formula | C6H11N3.2HCl |
| Storage | Desiccate at RT |
| CAS Number | 16503-22-3 |
| PubChem ID | 16078977 |
| InChI Key | AYUQICXJAMPXPF-UHFFFAOYSA-N |
| Smiles | Cl.Cl.CNCCC1=CNC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Nα-Methylhistamine dihydrochloride
References for Nα-Methylhistamine dihydrochloride
References are publications that support the biological activity of the product.
Hill et al (1990) Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45 PMID: 2164693
Schwartz et al (1990) A third histamine receptor subtype - characterization, localization and functions of the H3-receptor. Agents Actions 30 13 PMID: 1695431
Zweig et al (1992) Characterization of digitonin-solubilized bovine brain H3 histamine receptor coupled to a guanine nucleotide-binding protein. J.Neurochem. 59 1661 PMID: 1328529
View Related Products by Target
View Related Products by Product Action
Keywords: N-Methylhistamine dihydrochloride, N-Methylhistamine dihydrochloride supplier, Non-Selective, H3, agonists, Receptors, Histamine, histaminergic, Nalpha-Methylhistamine, dihydrochloride, 0573, Tocris Bioscience
Citations for Nα-Methylhistamine dihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Nα-Methylhistamine dihydrochloride.
Reviews for Nα-Methylhistamine dihydrochloride
There are currently no reviews for this product. Be the first to review Nα-Methylhistamine dihydrochloride and earn rewards!
Have you used Nα-Methylhistamine dihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.