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Submit ReviewN20C hydrochloride
Description: Non-competitive NMDA open-channel blocker
Chemical Name: 2-[(3,3-Diphenylpropyl)amino]acetamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for N20C hydrochloride
Selective, non-competitive NMDA receptor antagonist (IC50 = 5 μM); binds to the receptor-associated ion channel and prevents glutamate-induced Ca2+ influx. Displays neuroprotective activity in vivo. Brain-penetrant.
Technical Data for N20C hydrochloride
| M. Wt | 304.82 |
| Formula | C17H20N2O.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1177583-87-7 |
| PubChem ID | 16759164 |
| InChI Key | JCJDLPUASJEVRN-UHFFFAOYSA-N |
| Smiles | Cl.NC(=O)CNCCC(C1=CC=CC=C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for N20C hydrochloride
References for N20C hydrochloride
References are publications that support the biological activity of the product.
Planells-Cases et al (2002) A novel N-MthD.-aspartate receptor open channel blocker with in vivo neuroprotectant activity. J.Pharmacol.Exp.Ther. 302 163 PMID: 12065713
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Keywords: N20C hydrochloride, N20C hydrochloride supplier, Non-competitive, NMDA, receptor, open-channel, blockers, glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 2213, Tocris Bioscience
1 Citation for N20C hydrochloride
Citations are publications that use Tocris products. Selected citations for N20C hydrochloride include:
Roy et al (2014) Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase. J Biol Chem 9 e101883 PMID: 25007337
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