Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewNaftopidil hydrochloride
Discontinued Product
0597 has been discontinued.
View all Adrenergic α<sub>1</sub> Receptors products.
Description: α1 antagonist
Chemical Name: 4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Naftopidil hydrochloride
An α1-adrenoceptor antagonist with only weak antagonism at post-junctional α2 receptors; a potent, persistent antihypertensive and vasodilator.
Technical Data for Naftopidil hydrochloride
| M. Wt | 428.96 |
| Formula | C24H28N2O3.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1164469-60-6 |
| PubChem ID | 6603044 |
| InChI Key | VQAAEWMEVIOHTJ-UHFFFAOYSA-N |
| Smiles | Cl.COC1=C(C=CC=C1)N1CCN(CC(O)COC2=C3C=CC=CC3=CC=C2)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Naftopidil hydrochloride
References for Naftopidil hydrochloride
References are publications that support the biological activity of the product.
Borbe and Peter (1990) Alpha-1-adrenoceptor-binding material in rat plasma following single oral administration of naftopidil. Arzneimittelforschung 40 253 PMID: 1971750
Muramatsu et al (1991) Pharmacological profile of the novel alpha-adrenoceptor antagonist KT-611 (naftopidil). Jpn.J.Pharmacol. 55 391 PMID: 1677438
View Related Products by Target
View Related Products by Product Action
Keywords: Naftopidil hydrochloride, Naftopidil hydrochloride supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, antagonists, α1-adrenergic, alpha1-adrenergic, a1-adrenergic, Receptors, Adrenergic, Alpha-1, 0597, Tocris Bioscience
Citations for Naftopidil hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Naftopidil hydrochloride.
Reviews for Naftopidil hydrochloride
There are currently no reviews for this product. Be the first to review Naftopidil hydrochloride and earn rewards!
Have you used Naftopidil hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.