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Submit ReviewNaloxone 3-glucuronide carbonic acid salt
Description: Naloxone conjugate
Chemical Name: (5α)-4,5-Epoxy-14-hydroxy-6-oxo-17-(2-propenyl)morphinan-3-yl β-D-glucopyranosiduronic acid carbonic acid salt
Purity: ≥98% (HPLC)
Biological Activity
Naloxone 3-glucuronide carbonic acid salt is a Naloxone conjugate. Following oral administration induces delayed diarrhea, as well as milder and delayed withdrawal behavior and tail skin temperature (TST) response compared with naloxone in morphine-dependent rats.
Technical Data
| M. Wt | 565.52 |
| Formula | C25H29NO10.H2CO3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 121513881 |
| InChI Key | JWCWXAGEJDGZRX-IDUKCLALSA-N |
| Smiles | O=C(O)O.O=C3[C@H]5[C@]26C1=C(O5)C(OC4OC(C(O)=O)C(O)C(O)C4O)=CC=C1C[C@@H](N(CC6)CC=C)[C@@](O)2CC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Simpkins et al (1988) Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates. J.Pharmacol.Exp.Ther. 244 195 PMID: 3335997
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Keywords: Naloxone 3-glucuronide carbonic acid salt, Naloxone 3-glucuronide carbonic acid salt supplier, constipation, opioids, diarrhea, narcotics, glucuronide, conjugates, TST, tail, skin, temperature, Miscellaneous/Non-selective, Opioids, 5684, Tocris Bioscience
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