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Description: NLRP3 inflammasome inhibitor
Chemical Name: (T4)-[2-Acetyl-4,4,4-trichloro-3-(imino-κN)butanamidito-κO]diphenylboron
Purity: ≥98% (HPLC)
Biological Activity for NBC 6
NBC 6 is a NLRP3 inflammasome inhibitor (IC50 = 574 nM). Inhibits nigericin-induced inflammasome activation in THP-1 cells and Imiquimod (Cat. No. 3700) induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).
Licensing Information
Sold under license from the University of Manchester.
Technical Data for NBC 6
| M. Wt | 409.5 |
| Formula | C18H16BCl3N2O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2068818-02-8 |
| PubChem ID | 145237739 |
| InChI Key | VKECODDKRKQJNM-UHFFFAOYSA-N |
| Smiles | CC(C1=C(C(Cl)(Cl)Cl)N[B-](C2=CC=CC=C2)(C3=CC=CC=C3)[O+]=C1N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NBC 6
References for NBC 6
References are publications that support the biological activity of the product.
Baldwin et al (2017) Boron-based inhibitors of the NLRP3 inflammasome. Cell Chem.Biol. 24 1321 PMID: 28943355
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Keywords: NBC 6, NBC 6 supplier, NBC6, inflammasome, inhibitors, inhibits, NLRP3, Inflammasomes, 6925, Tocris Bioscience
Citations for NBC 6
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Currently there are no citations for NBC 6.
Reviews for NBC 6
Average Rating: 5 (Based on 1 Review.)
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NBC 6 can efficiently block pyroptosis induction.
By
Xiaogang Wang on 06/12/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: THP-1 cells
We ordered this product, combining with another pyroptosis inhibitor NSA, to confirm the induction of pyroptosis by staphylococcal virulence factors. We have shown that NSA significantly inhibited the release of LDH by THP-1 cells treated with staphylococcal products. To confirm that tested staphylococcal product induces pyroptosis, we also used 20 uM NBC 6 to pretreat THP-1 cells before incubating with staphylococcal product. Similarly, treatment of THP-1 cells with NBC 6 also significantly decreased the release of LDH in THP-1 cells treated by staphylococcal product.
