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Submit ReviewNGB 2904
Description: Potent and selective D3 antagonist
Chemical Name: N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for NGB 2904
NGB 2904 is a potent and selective dopamine D3 receptor antagonist (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC50 = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.
Compound Libraries for NGB 2904
NGB 2904 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for NGB 2904
| M. Wt | 530.92 |
| Formula | C28H29Cl2N3O.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 189061-11-8 |
| PubChem ID | 19366304 |
| InChI Key | PFIWYJNBKGCVFM-UHFFFAOYSA-N |
| Smiles | Cl.ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNC(=O)C2=CC=C3C(CC4=CC=CC=C34)=C2)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NGB 2904
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.27 | 25 | |
| ethanol | 2.65 | 5 |
Preparing Stock Solutions for NGB 2904
The following data is based on the product molecular weight 530.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 7.53 mL | 37.67 mL | 75.34 mL |
| 1.25 mM | 1.51 mL | 7.53 mL | 15.07 mL |
| 2.5 mM | 0.75 mL | 3.77 mL | 7.53 mL |
| 12.5 mM | 0.15 mL | 0.75 mL | 1.51 mL |
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Product Datasheets for NGB 2904
References for NGB 2904
References are publications that support the biological activity of the product.
Yuan et al (1998) NGB 2904 and NGB 2849: two highly selective DA D3 receptor antagonists. Bioorg.Med.Chem.Lett. 8 2715 PMID: 9873609
Xi et al (2006) The novel DA D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology 31 1393 PMID: 16205781
Pritchard et al (2007) The DA D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharmacol.Biochem.Behav. 86 718 PMID: 17408730
If you know of a relevant reference for NGB 2904, please let us know.
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Keywords: NGB 2904, NGB 2904 supplier, Potent, selective, D3, antagonists, Dopamine, Receptors, dopaminergic, NGB2904, 2635, Tocris Bioscience
2 Citations for NGB 2904
Citations are publications that use Tocris products. Selected citations for NGB 2904 include:
Nagata et al (2019) Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep 9 16438 PMID: 31712714
Axel et al (2010) Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and DA D1 receptor pathways in the diet-induced obese rat. Neuropsychopharmacology 35 1464 PMID: 20200509
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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