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Submit ReviewNGD 94-1
Description: Selective D4 receptor ligand
Chemical Name: 2-[4-[(2-Phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]-pyrimidine
Purity: ≥99% (HPLC)
Biological Activity for NGD 94-1
High affinity D4 receptor ligand; selective over D1, D2, D3 and D5 receptors. Displays antagonist activity at the human D4.2 receptor (Ki = 3.6 nM in transfected CHO cells) and exhibits agonist activity at the D4.4 receptor in HEK 293 cells.
Technical Data for NGD 94-1
| M. Wt | 320.39 |
| Formula | C18H20N6 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 178928-68-2 |
| PubChem ID | 188942 |
| InChI Key | OTVQCHUIPJYASM-UHFFFAOYSA-N |
| Smiles | C1(N2CCN(CC3=CN=C(C4=CC=CC=C4)N3)CC2)=NC=CC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NGD 94-1
References for NGD 94-1
References are publications that support the biological activity of the product.
Tallman et al (1997) I. NGD 94-1: Identification of a novel, high affinity antagonist at the human DA D4 receptor. J.Pharmacol.Exp.Ther. 282 1011 PMID: 9262370
Primus et al (1997) II. Localization and characterization of DA D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1. J.Pharmacol.Exp.Ther. 282 1020 PMID: 9262371
Gazi et al (1999) NGD 94-1 as an agonist at human recombinant DA D4.4 receptors expressed in HEK293 cells. Eur.J.Pharmacol. 372 R9 PMID: 10395031
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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