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Submit ReviewNitrendipine
Discontinued Product
0601 has been discontinued.
View all Ca<sub>V</sub>1.x Channels (L-type) products.
Description: CaV1.x blocker
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine dicarboxylic acid ethyl methyl ester
Purity: ≥99% (HPLC)
Biological Activity for Nitrendipine
Nitrendipine is a L-type calcium channel blocker. Induces autophagy.
Technical Data for Nitrendipine
| M. Wt | 360.37 |
| Formula | C18H20N2O6 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 39562-70-4 |
| PubChem ID | 4507 |
| InChI Key | PVHUJELLJLJGLN-UHFFFAOYSA-N |
| Smiles | CCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Nitrendipine
References for Nitrendipine
References are publications that support the biological activity of the product.
Costa et al (1996) Characterization of a voltage-dependent L-type calcium channel from rabbit and turtle brain. Neurochem.Res. 21 537 PMID: 8726959
Watanabe et al (1995) L-type calcium channel block by highly hydrophilic dihydropyridines in single ventricular cells of guinea-pig hearts. J.Mol.Cell.Cardiol. 27 1271 PMID: 8531209
Merck Index 12 6667
Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9 PMID: 21164513
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Keywords: Nitrendipine, Nitrendipine supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, Cav1.x, Autophagy, 0601, Tocris Bioscience
3 Citations for Nitrendipine
Citations are publications that use Tocris products. Selected citations for Nitrendipine include:
Rosenkranz et al (2009) Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT. Cardiovasc Res 83 778 PMID: 19460777
Schmitz et al (2009) Glutamate controls growth rate and branching of DArgic axons. J Neurosci 29 11973 PMID: 19776283
Subramanian and Morozov (2011) Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels. J Neurosci 31 4755 PMID: 21430174
Reviews for Nitrendipine
Average Rating: 5 (Based on 1 Review.)
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Nitrendipine was measured against other calcium channel blockers.
By
Anonymous on 02/20/2019
Species: Human
Nitrendipine blocks L-type calcium channels in smooth muscle cells and its effectiveness was measured against other calcium channel blockers.
