Home / Pharmacology / Enzymes / Cyclases / Adenylyl Cyclases / Adenylyl Cyclase Inhibitors / NKY 80

NKY 80

Cat. No. 5071 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Adenylyl cyclase inhibitor
Chemical Name: 2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NKY 80

NKY 80 is an inhibitor of adenylyl cyclase (AC). Exhibits greater affinity for AC5 over AC3 and AC2 (IC50 values are 8.3 μM, 132 μM and 1.7 mM respectively).

Compound Libraries for NKY 80

NKY 80 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NKY 80

M. Wt 229.23
Formula C12H11N3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 299442-43-6
PubChem ID 2772368
InChI Key SOJUSNIBPPMLCC-UHFFFAOYSA-N
Smiles NC(N=C2)=NC1=C2C(CC(C3=CC=CO3)C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NKY 80

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.92 100
ethanol 2.29 10 with gentle warming

Preparing Stock Solutions for NKY 80

The following data is based on the product molecular weight 229.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.36 mL 21.81 mL 43.62 mL
5 mM 0.87 mL 4.36 mL 8.72 mL
10 mM 0.44 mL 2.18 mL 4.36 mL
50 mM 0.09 mL 0.44 mL 0.87 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for NKY 80

References are publications that support the biological activity of the product.

Onda et al (2001) Type-specific regulation regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms. J.Biol.Chem. 276 47785 PMID: 11602596

Pierre et al (2009) Capturing adenylyl cyclases as potential drug targets. Nat.Rev.Drug Discov. 8 321 PMID: 19337273

If you know of a relevant reference for NKY 80, please let us know.

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1 Citation for NKY 80

Citations are publications that use Tocris products. Selected citations for NKY 80 include:

Jun et al (2020) In Vivo Imaging of the Coupling between Neuronal and CREB Activity in the Mouse Brain. Neuron 105 799-812.e5 PMID: 31883788

Do you know of a great paper that uses NKY 80 from Tocris? Please let us know.

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