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Submit ReviewNNC 05-2090 hydrochloride
Description: GABA uptake inhibitor; moderately BGT-1 selective
Chemical Name: 1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for NNC 05-2090 hydrochloride
NNC 05-2090 hydrochloride is a GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (Ki values are 1.4, 15, 19 and 41 μM for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays affinity at α1- and D2-receptors (IC50 values are 266 and 1632 nM respectively).
Technical Data for NNC 05-2090 hydrochloride
| M. Wt | 451.01 |
| Formula | C27H30N2O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 184845-18-9 |
| PubChem ID | 18782760 |
| InChI Key | WDFXPKKFSNMGOO-UHFFFAOYSA-N |
| Smiles | Cl.COC1=C(C=CC=C1)C1(O)CCN(CCCN2C3=C(C=CC=C3)C3=C2C=CC=C3)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NNC 05-2090 hydrochloride
References for NNC 05-2090 hydrochloride
References are publications that support the biological activity of the product.
Thomsen et al (1997) 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter. Br.J.Pharmacol. 120 983 PMID: 9134205
Dalby et al (1997) Anticonvulsive properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1. Epilepsy Res. 28 51 PMID: 9255599
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Keywords: NNC 05-2090 hydrochloride, NNC 05-2090 hydrochloride supplier, GABA, reuptake, inhibitors, inhibits, moderately, BGT-1, selective, Transporters, Monoamine, Neurotransmitter, NNC052090, hydrochloride, 2747, Tocris Bioscience
1 Citation for NNC 05-2090 hydrochloride
Citations are publications that use Tocris products. Selected citations for NNC 05-2090 hydrochloride include:
Wang et al (2015) Neuronal γ-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA. Sleep 9 188 PMID: 26041994
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.