Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewNNC 63-0532
Description: Potent non-peptide NOP agonist; brain penetrant
Chemical Name: 8-(1-Naphthalenylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-3-acetic acid, methyl ester
Purity: ≥98% (HPLC)
Biological Activity for NNC 63-0532
NNC 63-0532 is a potent non-peptide agonist for the NOP receptor (EC50 = 305 nM, Ki = 7.3 nM); ~ 12-fold selective over other receptors. Centrally active following systemic administration in vivo.
Compound Libraries for NNC 63-0532
NNC 63-0532 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for NNC 63-0532
| M. Wt | 443.54 |
| Formula | C27H29N3O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 250685-44-0 |
| PubChem ID | 3906780 |
| InChI Key | DSEIKQVUTKGLGT-UHFFFAOYSA-N |
| Smiles | COC(=O)CN1CN(C2=CC=CC=C2)C2(CCN(CC3=CC=C4C=CC=CC4=C3)CC2)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NNC 63-0532
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 2.22 | 5 | |
| DMSO | 22.18 | 50 |
Preparing Stock Solutions for NNC 63-0532
The following data is based on the product molecular weight 443.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.51 mL | 22.55 mL | 45.09 mL |
| 2.5 mM | 0.9 mL | 4.51 mL | 9.02 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.51 mL |
| 25 mM | 0.09 mL | 0.45 mL | 0.9 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for NNC 63-0532
References for NNC 63-0532
References are publications that support the biological activity of the product.
Thomsen and Hohlweg (2000) (8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]-dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist. Br.J.Pharmacol. 131 903 PMID: 11053209
If you know of a relevant reference for NNC 63-0532, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: NNC 63-0532, NNC 63-0532 supplier, Potent, non-peptide, NOP, agonists, brain, penetrant, Nociceptin, Receptors, ORL1, OP4, Opioid, NNC630532, 1780, Tocris Bioscience
1 Citation for NNC 63-0532
Citations are publications that use Tocris products. Selected citations for NNC 63-0532 include:
Gear et al (2014) NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids. Neuroscience 257 139 PMID: 24188792
Do you know of a great paper that uses NNC 63-0532 from Tocris? Please let us know.
Reviews for NNC 63-0532
There are currently no reviews for this product. Be the first to review NNC 63-0532 and earn rewards!
Have you used NNC 63-0532?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.