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Submit ReviewNocistatin (bovine)
Description: Opposes action of nociceptin
Biological Activity for Nocistatin (bovine)
An endogenous peptide derived from the same precursor as nociceptin, which is able to block nociceptin-induced allodynia and hyperalgesia and may play an opposing role in pain transmission. Shown to reverse nociceptin inhibition of glutamate release from rat brain slices; also modulates 5-HT transmission in the mouse neocortex via mechanisms separate from nociceptin/orphanin FQ.
Technical Data for Nocistatin (bovine)
| M. Wt | 1927.07 |
| Formula | C82H135N21O32 |
| Sequence | TEPGLEEVGEIEQKQLQ |
| Storage | Desiccate at -20°C |
| CAS Number | 208253-85-4 |
| PubChem ID | 24868191 |
| InChI Key | GUPWDFZVRDNEEX-GFTPUIGSSA-N |
| Smiles | [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Nocistatin (bovine)
References for Nocistatin (bovine)
References are publications that support the biological activity of the product.
Fantin et al (2007) Nocistatin inhibits 5-hydroxytryptamine release in the mouse neocortex via presynaptic Gi/o protein linked pathways. Br.J.Pharmacol. 152 549 PMID: 17618307
Nicol et al (1998) Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices. Eur.J.Pharmacol. 356 R1 PMID: 9774260
Okuda-Ashitaka et al (1998) Nocistatin, a peptide that blocks nociceptin action in pain transmission. Nature 392 286 PMID: 9521323
Yamamoto et al (1999) Effect of nocistatin and its interaction with nociceptin/orphanin FQ on the rat formalin test. Neurosci.Lett. 262 179 PMID: 10218885
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Keywords: Nocistatin (bovine), Nocistatin (bovine) supplier, blocker, nociceptin, receptors, ORL1, OP4, NOP, opioid, reverses, Receptors, 1118, Tocris Bioscience
Citations for Nocistatin (bovine)
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