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Nor NOHA monoacetate

Cat. No. 6370 2 Citations Submit a Review Datasheet / COA / SDS
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Description: Arginase inhibitor
Chemical Name: (2S)-2-Amino-4-[[(hydroxyamino)iminomethyl]amino]butanoic acid monoacetate
Datasheet
Citations (2)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Nor NOHA monoacetate

Nor NOHA monoacetate is a reversible, competitive arginase inhibitor (IC50 = 2 μM). Exhibits 10-fold selectivity for human type II arginase over type I. Enhances the effect of acetylcholine on isolated aortic and mesenteric arterial rings. Inhibits growth of lung carcinoma implants in mice.

Technical Data for Nor NOHA monoacetate

M. Wt 236.23
Formula C5H12N4O3.C2H4O2
Storage Store at -20°C
CAS Number 2250019-93-1
PubChem ID 131648256
InChI Key RYUGHGOGNIYFKU-DFWYDOINSA-N
Smiles N[C@@H](CCNC(NO)=N)C(O)=O.O=C(O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nor NOHA monoacetate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 23.62 100

Preparing Stock Solutions for Nor NOHA monoacetate

The following data is based on the product molecular weight 236.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.23 mL 21.17 mL 42.33 mL
5 mM 0.85 mL 4.23 mL 8.47 mL
10 mM 0.42 mL 2.12 mL 4.23 mL
50 mM 0.08 mL 0.42 mL 0.85 mL

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Product Datasheets for Nor NOHA monoacetate

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Nor NOHA monoacetate

References are publications that support the biological activity of the product.

Custot et al (1997) The new α-amino acid Nω-hydroxy-nor-L-arginine: a high affinity inhibitor of arginase well adapted to bind to its manganese cluster. J.Am.Chem.Soc. 119 4086

Colleluori and Ash et al (2001) Classical and slow-binding inhibitors of human type II arginase. Biochemistry 40 9356 PMID: 11478904

Huynh et al (2009) The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries. Br.J.Pharmacol. 156 84 PMID: 19133993

Rodriguez et al (2004) Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res. 64 5839 PMID: 15313928

If you know of a relevant reference for Nor NOHA monoacetate, please let us know.

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Keywords: Nor NOHA monoacetate, Nor NOHA monoacetate supplier, arginase, inhibitors, inhibits, reversible, competitive, 189302-40-7, Other, Hydrolases, Immune, Checkpoints, 6370, Tocris Bioscience

2 Citations for Nor NOHA monoacetate

Citations are publications that use Tocris products. Selected citations for Nor NOHA monoacetate include:

Rogier C et al (2020) Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158. J Struct Biol X 4 100014 PMID: 32647818

Rogier C et al (2020) High-Throughput Fluorescence-Based Activity Assay for Arginase-1. SLAS Discov 25 1018-1025 PMID: 32418491

Do you know of a great paper that uses Nor NOHA monoacetate from Tocris? Please let us know.

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