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Submit ReviewNPEC-caged-dopamine
Description: Caged dopamine
Chemical Name: (N)-1-(2-Nitrophenyl)ethylcarboxy-3,4-dihydroxyphenethylamine
Purity: ≥99% (HPLC)
Biological Activity for NPEC-caged-dopamine
NPEC-caged-dopamine is a NPEC ((N)-1-(2-nitrophenyl)ethyl) caged version of dopamine (Cat. No 3548); releases dopamine leading to D1 receptor activation upon UV light illumination (360 nm). Induces PKA activation and c-Fos expression in cortical and striatal neurons, with striatal neurons demonstrating a significantly greater detection and sensitivity to sub-second dopamine signals as compared to cortical neurons.
Technical Data for NPEC-caged-dopamine
| M. Wt | 346.33 |
| Formula | C17H18N2O6 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1257326-23-0 |
| PubChem ID | 90488901 |
| InChI Key | PDNNZLULXSQJGZ-UHFFFAOYSA-N |
| Smiles | CC(OC(NCCC2=CC=C(O)C(O)=C2)=O)C1=C([N+]([O-])=O)C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NPEC-caged-dopamine
References for NPEC-caged-dopamine
References are publications that support the biological activity of the product.
Castro et al (2013) Striatal neurones have a specific ability to respond to phasic DA release. J.Physiol. 591 3197 PMID: 23551948
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2 Citations for NPEC-caged-dopamine
Citations are publications that use Tocris products. Selected citations for NPEC-caged-dopamine include:
Yapo et al (2017) Detection of phasic DA by D1 and D2 striatal medium spiny neurons. J.Physiol. 595 7451 PMID: 28782235
Castro et al (2013) Striatal neurones have a specific ability to respond to phasic DA release. J.Physiol. 591 3197 PMID: 23551948
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.