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Submit Review[Nphe1]Nociceptin(1-13)NH2
Description: Selective, competitive nociceptin antagonist
Biological Activity for [Nphe1]Nociceptin(1-13)NH2
[Nphe1]Nociceptin(1-13)NH2 is a selective and competitive nociceptin receptor antagonist, devoid of any agonist activity. Binds selectively to recombinant nociceptin receptors (pKi = 8.4), and competitively antagonizes the actions of nociceptin in vitro and in vivo.
Technical Data for [Nphe1]Nociceptin(1-13)NH2
| M. Wt | 1381.6 |
| Formula | C61H100N22O15 |
| Sequence |
GGGFTGARKSARK (Modifications: Gly-1 = N-Bn-Gly, Lys-13 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 267234-08-2 |
| PubChem ID | 10654047 |
| InChI Key | NMBZIPCESQREMT-UVDGFCMYSA-N |
| Smiles | [H]N(CC(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O)CC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for [Nphe1]Nociceptin(1-13)NH2
References for [Nphe1]Nociceptin(1-13)NH2
References are publications that support the biological activity of the product.
Calo et al (2000) Characterization of [Nphe1]nociceptin(1-13)NH2, a new selective nociceptin receptor antagonist. Br.J.Pharmacol. 129 1183 PMID: 10725267
Hashimoto et al (2000) Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor. Neurosci.Lett. 278 109 PMID: 10643813
Pheng et al (2000) [Nphe1]nociceptin-(1-13)NH2 selectively antagonizes nociceptin effects in the rabbit isolated ileum. Eur.J.Pharmacol. 397 383 PMID: 10844138
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Keywords: [NPhe1]Nociceptin(1-13)NH2, [NPhe1]Nociceptin(1-13)NH2 supplier, Selective, competitive, nociceptin, antagonists, Receptors, ORL1, OP4, NOP, Opioid, 1308, Tocris Bioscience
3 Citations for [Nphe1]Nociceptin(1-13)NH2
Citations are publications that use Tocris products. Selected citations for [Nphe1]Nociceptin(1-13)NH2 include:
Schmid et al (2017) Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics. Cell 171 1165 PMID: 29149605
Kallupi et al (2014) Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats. Neuropsychopharmacology 39 1081 PMID: 24169802
Wu & Liu (2018) ORL1 activation mediates a novel ORL1 receptor agonist SCH221510 analgesia in neuropathic pain in rats. J Mol Neurosci 66 10 PMID: 30074175
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