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Submit ReviewNPS 2390
Description: Group I mGlu antagonist
Chemical Name: N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide
Purity: ≥99% (HPLC)
Biological Activity for NPS 2390
NPS 2390 is a group I mGlu antagonist; displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors. Thought to act on a site separate from the glutamate binding pocket.
Compound Libraries for NPS 2390
NPS 2390 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for NPS 2390
| M. Wt | 307.39 |
| Formula | C19H21N3O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 226878-01-9 |
| PubChem ID | 7067728 |
| InChI Key | ZKFVOZCCAXQXBU-UHFFFAOYSA-N |
| Smiles | O=C(C4=NC(C=CC=C5)=C5N=C4)NC1(CC3C2)CC(C3)CC2C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NPS 2390
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.37 | 50 | |
| ethanol | 15.37 | 50 |
Preparing Stock Solutions for NPS 2390
The following data is based on the product molecular weight 307.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.51 mL | 32.53 mL | 65.06 mL |
| 2.5 mM | 1.3 mL | 6.51 mL | 13.01 mL |
| 5 mM | 0.65 mL | 3.25 mL | 6.51 mL |
| 25 mM | 0.13 mL | 0.65 mL | 1.3 mL |
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Product Datasheets for NPS 2390
References for NPS 2390
References are publications that support the biological activity of the product.
Lavreysen et al (2003) [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol.Pharmacol. 63 1082 PMID: 12695537
Mabire et al (2005) Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists. J.Med.Chem. 48 2134 PMID: 15771457
van Wagenen et al (2000) Structure-activity relationship studies of NPS 2390: a potent and selective group I metabotropic glutamate receptor antagonist. Abstr.Soc.Neurosci. Program No. 618.3.
If you know of a relevant reference for NPS 2390, please let us know.
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Keywords: NPS 2390, NPS 2390 supplier, NPS2390, type, I, metabotropic, glutamate, mglu, mglur1, mglur5, antagonists, Glutamate, (Metabotropic), Group, Receptors, 4134, Tocris Bioscience
2 Citations for NPS 2390
Citations are publications that use Tocris products. Selected citations for NPS 2390 include:
Lezmy et al (2021) Astrocyte Ca 2+-evoked ATP release regulates myelinated axon excitability and conduction speed. Science 374 eabh2858 PMID: 34648330
Li et al (2016) Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor. Oxid Med Cell Longev 2016 5203801 PMID: 27965733
Do you know of a great paper that uses NPS 2390 from Tocris? Please let us know.
Reviews for NPS 2390
Average Rating: 5 (Based on 1 Review.)
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Use of NPS 2390 to isolate GABA-A receptor response.
By
Anonymous on 09/17/2019
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Cerebellum
NPS 2390 was used as a specific blocker of mGluR1 and mGluR5, to isolate pharmacologically response of GABA-A receptors. 10 microM of NPS 2390 in perfusion solution generated a full block of mGluR group I receptor activity, thus leaving a clear GABA-ergic response. Figure: single-channel openings of GABA-A receptor after application of NPS 2390.
Compound requires sonication to be dissolved.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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