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Submit ReviewNQ 301
Description: Selective CD45 inhibitor
Chemical Name: 2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione
Purity: ≥98% (HPLC)
Biological Activity for NQ 301
NQ 301 is a selective CD45 inhibitor (IC50 = 200 nM). Exhibits >200-fold selectivity for CD45 over six related protein tyrosine phosphatases. Increases phosphorylation of Lck in Jurkat cells and reduces T cell receptor signaling in acitvated splenocytes in vitro. Blocks inflammation in a delayed-type hypersensitivity model in vivo.
Technical Data for NQ 301
| M. Wt | 325.75 |
| Formula | C18H12ClNO3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 130089-98-4 |
| PubChem ID | 781109 |
| InChI Key | LSQZKIQSQHZVQS-UHFFFAOYSA-N |
| Smiles | O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NQ 301
References for NQ 301
References are publications that support the biological activity of the product.
Perron et al (2014) Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo. Mol.Pharmacol. 85 553 PMID: 24473749
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Citations for NQ 301
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