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NS 2028

Cat. No. 4517 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent soluble guanylyl cyclase (sGC) inhibitor
Chemical Name: 8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NS 2028

NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). Blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 values are 17 and 20 nM respectively). Inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).

Compound Libraries for NS 2028

NS 2028 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NS 2028

M. Wt 269.05
Formula C9H5BrN2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 204326-43-2
PubChem ID 4551
InChI Key MUDRLQRJCGJJTB-UHFFFAOYSA-N
Smiles BrC1=CC=C(OCC(N23)=NOC3=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NS 2028

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.91 100
ethanol 5.38 20

Preparing Stock Solutions for NS 2028

The following data is based on the product molecular weight 269.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.72 mL 18.58 mL 37.17 mL
5 mM 0.74 mL 3.72 mL 7.43 mL
10 mM 0.37 mL 1.86 mL 3.72 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets for NS 2028

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for NS 2028

References are publications that support the biological activity of the product.

von Wantoch Rekowski et al (2010) Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase. Bioorg.Med.Chem. 18 1288 PMID: 20036129

Morbidelli et al (2010) The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. Am.J.Physiol.Regul.Integr.Comp.Physiol. 298 R824 PMID: 20032260

Olesen et al (1998) Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. Br.J.Pharmacol. 123 299 PMID: 9489619

If you know of a relevant reference for NS 2028, please let us know.

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1 Citation for NS 2028

Citations are publications that use Tocris products. Selected citations for NS 2028 include:

Ping et al (2019) 17β-Estradiol nongenomically induces vascular endothelial H2S release by promoting phosphorylation of cystathionine γ-lyase. J Biol Chem 294 15577-15592 PMID: 31439665

Do you know of a great paper that uses NS 2028 from Tocris? Please let us know.

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