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Submit ReviewNSC 23005 sodium
Description: Potently promotes HSC expansion ; p18INK inhibitor
Chemical Name: 4-[(Cyclohexylamino)sulfonyl]benzoic acid sodium salt
Purity: ≥99% (HPLC)
Biological Activity for NSC 23005 sodium
NSC 23005 sodium is a p18INK inhibitor. Potently promotes hematopoietic stem cell (HSC) expansion (ED50 = 5.21 nM). Exhibits no effect on leukemia cell proliferation.
Compound Libraries for NSC 23005 sodium
NSC 23005 sodium is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for NSC 23005 sodium
| M. Wt | 305.33 |
| Formula | C13H16NNaO4S |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1796596-46-7 |
| PubChem ID | 122705986 |
| InChI Key | MLHFBDVMTRIQMW-UHFFFAOYSA-M |
| Smiles | O=S(C1=CC=C(C([O-])=O)C=C1)(NC2CCCCC2)=O.[Na+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NSC 23005 sodium
References for NSC 23005 sodium
References are publications that support the biological activity of the product.
Xie et al (2015) Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci.Rep. 5 18115 PMID: 26681454
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Stem Cell Research Product Guide
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Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.