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Submit ReviewNSC 3852
Description: Histone deacetylase inhibitor
Chemical Name: 5-Nitroso-8-quinolinol
Biological Activity for NSC 3852
NSC 3852 is a histone deacetylase inhibitor. Causes cell differentiation and antiproliferative activity in MCF-7 human breast cancer cells in vitro and displays antitumor activity in vivo. Also exhibits antiproliferative, proapoptotic and differentiation effects in pediatric acute myeloid leukemia cell lines.
Technical Data for NSC 3852
| M. Wt | 174.16 |
| Formula | C9H6N2O2 |
| Storage | Store at RT |
| CAS Number | 3565-26-2 |
| PubChem ID | 19103 |
| InChI Key | RZWRYPGAUIOOMK-UHFFFAOYSA-N |
| Smiles | OC1=C2N=CC=CC2=C(C=C1)N=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NSC 3852
References for NSC 3852
References are publications that support the biological activity of the product.
Martirosyan et al (2004) Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell model. Biochem.Pharmacol. 68 1729 PMID: 15450938
Martirosyan et al (2006) Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells. J.Pharmacol.Exp.Ther. 317 546 PMID: 16497787
Wiggers et al (2019) Epigenetic drug screen identifies the histone deacetylase inhibitor NSC3852 as a potential novel drug for the treatment of pediatric acute myeloid leukemia. Pediatr.Blood Cancer. PMID: 31044544
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Keywords: NSC 3852, NSC 3852 supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, NSC3852, epigenetics, Non-selective, HDACs, Non-Selective, 2521, Tocris Bioscience
Citations for NSC 3852
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.