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Submit ReviewNSC 405020
Description: Histone deacetylase inhibitor
Chemical Name: 3,4-Dichloro-N-(1-methylbutyl)benzamide
Purity: ≥99% (HPLC)
Biological Activity for NSC 405020
NSC 405020 is a membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo. Displays no effect on the catalytic activity of MT1-MMP or MMP-2.
Compound Libraries for NSC 405020
NSC 405020 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for NSC 405020
| M. Wt | 260.16 |
| Formula | C12H15Cl2NO |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 7497-07-6 |
| PubChem ID | 346721 |
| InChI Key | ARDYECYBETXQFD-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C(NC(C)CCC)=O)C=C1Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NSC 405020
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.02 | 100 | |
| ethanol | 26.02 | 100 |
Preparing Stock Solutions for NSC 405020
The following data is based on the product molecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.84 mL | 19.22 mL | 38.44 mL |
| 5 mM | 0.77 mL | 3.84 mL | 7.69 mL |
| 10 mM | 0.38 mL | 1.92 mL | 3.84 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.77 mL |
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Product Datasheets for NSC 405020
References for NSC 405020
References are publications that support the biological activity of the product.
Remacle et al (2012) Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res. 72 2339 PMID: 22406620
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Keywords: NSC 405020, NSC 405020 supplier, NSC405020, Membrane, type-1, matrix, metalloproteinase, MT1-MMP, inhibitors, inhibits, hemopexin, domains, PEX, pro-tumorigenic, antitumor, MMP2, MMP-2, MMP, Matrix, Metalloprotease, Class, I, HDACs, 4902, Tocris Bioscience
5 Citations for NSC 405020
Citations are publications that use Tocris products. Selected citations for NSC 405020 include:
Kumar et al (2018) MMP Secretion Rate and Inter-invadopodia Spacing Collectively Govern Cancer Invasiveness. Biophys J 114 650 PMID: 29414711
Clancy et al (2015) Regulated delivery of molecular cargo to invasive tumour-derived microvesicles. Proc Natl Acad Sci U S A 6 6919 PMID: 25897521
Helena et al (2017) Mesenchymal stem cells differentially affect the invasion of distinct glioblastoma cell lines. Oncotarget 8 25482-25499 PMID: 28424417
Bernard et al (2022) Megakaryocytes form linear podosomes devoid of digestive properties to remodel medullar matrix. Sci Rep 12 6255 PMID: 35428815
Isabelle et al (2020) Basement membrane remodelling regulates mouse embryogenesis. Nature 582 253-258 PMID: 32523119
Do you know of a great paper that uses NSC 405020 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
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