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Submit ReviewNVP CXCR2 20
Description: Potent and selective CXCR2 antagonist
Chemical Name: 4-Cyclopropyl-2-[[(2,3-difluorophenyl)methyl]thio]-1,6-dihydro-6-oxo5-pyrimidinecarbonitrile
Purity: ≥98% (HPLC)
Biological Activity for NVP CXCR2 20
Potent and selective CXCR2 antagonist (IC50 = 40 nM). Exhibits selectivity for CXCR2 over a panel of 49 other GPCRs. Orally bioavailable.
Compound Libraries for NVP CXCR2 20
NVP CXCR2 20 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for NVP CXCR2 20
| M. Wt | 319.33 |
| Formula | C15H11F2N3OS |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1029521-30-9 |
| PubChem ID | 24955240 |
| InChI Key | PHHZYKZFEBRXAL-UHFFFAOYSA-N |
| Smiles | OC1=C(C#N)C(C2CC2)=NC(SCC3=CC=CC(F)=C3F)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NVP CXCR2 20
References for NVP CXCR2 20
References are publications that support the biological activity of the product.
Porter et al (2014) The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists. Bioorg.Med.Chem.Lett. 24 3285 PMID: 24974342
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Keywords: NVP CXCR2 20, NVP CXCR2 20 supplier, NVPCXCR220, chemokine, cxc, receptors, antagonists, antagonism, orally, bioavailable, potent, selective, Chemokine, CXC, Receptors, 5660, Tocris Bioscience
Citations for NVP CXCR2 20
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