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Submit ReviewO-Phospho-L-serine
Discontinued Product
0238 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
Description: Group III mGlu agonist
Alternative Names: L-SOP
Chemical Name: L-Serine-O-phosphate
Biological Activity for O-Phospho-L-serine
O-Phospho-L-serine is a group III metabotropic glutamate receptor agonist; analog of L-AP4 (Cat. No. 0103). Neuroprotective against excitotoxicity in cortical cell cultures. Inhibits proliferation and enhances neuronal differentiation in progenitor cells.
Technical Data for O-Phospho-L-serine
| M. Wt | 185.07 |
| Formula | C3H8NO6P |
| Storage | Store at RT |
| CAS Number | 407-41-0 |
| PubChem ID | 68841 |
| InChI Key | BZQFBWGGLXLEPQ-REOHCLBHSA-N |
| Smiles | [H][C@@](COP(O)(O)=O)(N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for O-Phospho-L-serine
References for O-Phospho-L-serine
References are publications that support the biological activity of the product.
Bruno et al (1996) Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures. Eur.J.Pharmacol. 310 61 PMID: 8880068
Eriksen and Thomsen (1995) [3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a. Br.J.Pharmacol. 116 3279 PMID: 8719808
Thoreson and Ulphani (1995) Pharmacology of selective and non-selective metabotropic glutamate receptor agonists at L-AP4 receptors in ON bipolar cells. Brain Res. 676 93 PMID: 7796182
Saxe et al (2007) A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation. Chem.Biol. 14 1019 PMID: 17884634
Yang et al (2016) A chemical biology route to site-specific authentic protein modifications. Science 354 623 PMID: 27708052
Park et al (2011) Expanding the genetic code of Escherichia coli with phosphoserine. Science 333 1151 PMID: 21868676
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Keywords: O-Phospho-L-serine, O-Phospho-L-serine supplier, Group, III, mGlur, agonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, stem, cells, o-phosphoserine, sep, L-SOP, (Metabotropic), Neural, Stem, Cells, 0238, Tocris Bioscience
2 Citations for O-Phospho-L-serine
Citations are publications that use Tocris products. Selected citations for O-Phospho-L-serine include:
Mathiesen et al (2003) Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br J Pharmacol 138 1026 PMID: 12684257
Jiang et al (2006) Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism. J Neurosci 26 4318 PMID: 16624952
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Literature in this Area
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