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Submit ReviewO8 OGG1 Inhibitor
Description: Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor
Chemical Name: 3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide
Purity: ≥98% (HPLC)
Biological Activity for O8 OGG1 Inhibitor
O8 OGG1 Inhibitor is a potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.
Compound Libraries for O8 OGG1 Inhibitor
O8 OGG1 Inhibitor is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for O8 OGG1 Inhibitor
| M. Wt | 261.13 |
| Formula | C9H6Cl2N2OS |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 350997-39-6 |
| PubChem ID | 874733 |
| InChI Key | HSSHUDKWJRJKPV-UHFFFAOYSA-N |
| Smiles | NNC(=O)C1=C(Cl)C2=C(Cl)C=CC=C2S1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for O8 OGG1 Inhibitor
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.11 | 100 |
Preparing Stock Solutions for O8 OGG1 Inhibitor
The following data is based on the product molecular weight 261.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.83 mL | 19.15 mL | 38.3 mL |
| 5 mM | 0.77 mL | 3.83 mL | 7.66 mL |
| 10 mM | 0.38 mL | 1.91 mL | 3.83 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.77 mL |
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Product Datasheets for O8 OGG1 Inhibitor
References for O8 OGG1 Inhibitor
References are publications that support the biological activity of the product.
Donley et al (2015) Small molecule inhibitors of 8-oxoguanine DNA glycosylase-1 (OGG1). ACS Chem.Biol. 10 2334 PMID: 26218629
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Keywords: O8 OGG1 Inhibitor, O8 OGG1 Inhibitor supplier, O8OGG1, Inhibitor, inhibitors, inhibits, potent, selective, 8-Oxoguanine, DNA, Glycosylase-1, OGG1, base, excision, repair, pathway, BER, Glycosylases, 6236, Tocris Bioscience
1 Citation for O8 OGG1 Inhibitor
Citations are publications that use Tocris products. Selected citations for O8 OGG1 Inhibitor include:
Gustavo F et al (2021) Ginkgolic Acid Inhibits Coronavirus Strain 229E Infection of Human Epithelial Lung Cells. Pharmaceuticals (Basel) 14 PMID: 34681204
Do you know of a great paper that uses O8 OGG1 Inhibitor from Tocris? Please let us know.
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