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Submit ReviewOBAA
Description: Phospholipase A2 inhibitor
Chemical Name: 4-(4-Octadecylphenyl)-4-oxobutenoic acid
Biological Activity for OBAA
OBAA is a potent inhibitor of phospholipase A2 (IC50 = 70 nM). Reduces bronchospasm in guinea pigs in vivo.
Technical Data for OBAA
| M. Wt | 428.65 |
| Formula | C28H44O3 |
| Storage | Desiccate at +4°C |
| CAS Number | 221632-26-4 |
| PubChem ID | 5353842 |
| InChI Key | ZBESASFHIWDSCJ-WCWDXBQESA-N |
| Smiles | CCCCCCCCCCCCCCCCCCC1=CC=C(C=C1)C(=O)\C=C\C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for OBAA
References for OBAA
References are publications that support the biological activity of the product.
Kohler et al (1991) Phospholipase-A2 inhibition by alkylbenzoyl acrylic acids. Agents Actions 32 70 PMID: 2058477
Kohler et al (1992) Phospholipase A2 inhibition by alkylbenzoyl acrylic acids. Biochem.Pharmacol. 44 805 PMID: 1324685
Madi et al (1991) Allergen-induced bronchospasm in passively sensitized guinea-pigs - influence of new substances in comparison to reference compounds. Agents Actions 32 144 PMID: 2058463
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Keywords: OBAA, OBAA supplier, Phospholipases, A2, inhibitors, inhibits, PLA, sPLA2, Esterases, 0606, Tocris Bioscience
2 Citations for OBAA
Citations are publications that use Tocris products. Selected citations for OBAA include:
Bianca et al (2010) Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2. Nat Commun 161 1835 PMID: 20825409
Kuo et al (2016) MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery. Am J Physiol Heart Circ Physiol 310 H71 PMID: 26519030
Reviews for OBAA
Average Rating: 5 (Based on 1 Review.)
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used this drug as an inhibitor.
By
Anonymous on 10/05/2017
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: macrophages
Pretreat mouse macrophage cells with this inhibitor prior to the bacterial stimulation
