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Submit ReviewOlopatadine hydrochloride
Description: H1 antagonist; ocular antiallergic agent
Chemical Name: (Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Olopatadine hydrochloride
Olopatadine hydrochloride is a histamine H1 receptor antagonist (Ki = 31.6 nM). Inhibits the release of histamine, prostaglandin D2 and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.
Compound Libraries for Olopatadine hydrochloride
Olopatadine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Olopatadine hydrochloride
| M. Wt | 373.87 |
| Formula | C21H23NO3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 140462-76-6 |
| PubChem ID | 5282402 |
| InChI Key | HVRLZEKDTUEKQH-NOILCQHBSA-N |
| Smiles | O=C(CC(C=C3)=CC/1=C3OCC(C=CC=C2)=C2C1=C\CCN(C)C)O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Olopatadine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 28.04 | 75 | |
| DMSO | 37.39 | 100 |
Preparing Stock Solutions for Olopatadine hydrochloride
The following data is based on the product molecular weight 373.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.67 mL | 13.37 mL | 26.75 mL |
| 5 mM | 0.53 mL | 2.67 mL | 5.35 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.67 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
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Product Datasheets for Olopatadine hydrochloride
References for Olopatadine hydrochloride
References are publications that support the biological activity of the product.
Tamura et al (2007) Olopatidine ameliorates rat experimental cutaneous inflammation by improving skin barrier function. Pharmacology 81 118 PMID: 17962722
Sharif et al (1996) Characterization of the ocular antiallergic and antihistaminic effects of olopatidine (AL-4943A), a novel drug for treating ocular allergic diseases. J.Pharmacol.Exp.Ther. 278 1252 PMID: 8819509
If you know of a relevant reference for Olopatadine hydrochloride, please let us know.
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Keywords: Olopatadine hydrochloride, Olopatadine hydrochloride supplier, histamine, H1, antagonists, antihistamines, mast, cell, stabilizers, ocular, antiallergic, Histamine, Receptors, 4241, Tocris Bioscience
Citations for Olopatadine hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.