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Description: Reversible photoactive TRPA1 activator
Chemical Name: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-4-thiazolidinone
Purity: ≥99% (HPLC)
Biological Activity for Optovin
Optovin is a reversible photoactive TRPA1 activator. Stimulates human TRPA1 channels in vitro and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50 = 2 μM) and mice, in vivo.
Technical Data for Optovin
| M. Wt | 315.41 |
| Formula | C15H13N3OS2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 348575-88-2 |
| PubChem ID | 1365101 |
| InChI Key | YISGMOZSGOGYOU-NTUHNPAUSA-N |
| Smiles | S=C(N2)S/C(C2=O)=C/C1=C(C)N(C3=CN=CC=C3)C(C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Optovin
References for Optovin
References are publications that support the biological activity of the product.
Kokel et al (2013) Photochemical activation of TRPA1 channels in neurons and animals. Nat.Chem.Biol. 9 257 PMID: 23396078
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Keywords: Optovin, Optovin supplier, photoactive, TRPA1, TRP, channels, activators, photoactivation, photoswitchable, Photoswitchable, Ligands, 4901, Tocris Bioscience
3 Citations for Optovin
Citations are publications that use Tocris products. Selected citations for Optovin include:
Jon et al (2021) Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways. Cell Host Microbe 29 179-196.e9 PMID: 33352109
Sandy et al (2022) Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish. Nat Commun 13 2573 PMID: 35545618
James A et al (2019) Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets. Nat Neurosci 22 1477-1492 PMID: 31358991
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