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Submit ReviewOrexin A (human, rat, mouse)
Description: Endogenous agonist at OX1 and OX2
Purity: ≥95% (HPLC)
Biological Activity for Orexin A (human, rat, mouse)
Orexin A (human, rat, mouse) is an endogenous agonist with high affinity at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Orexin A stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Orexin A impairs neurogenesis and hippocampal plasticity in mice. Orexin A improves glucose control and beta cell functions in type 2 diabetic animals.
Technical Data for Orexin A (human, rat, mouse)
| M. Wt | 3561.12 |
| Formula | C152H243N47O44S4 |
| Sequence |
XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL (Modifications: X = Glp, Disulfide bridges: 6-12, 7-14, Leu-33 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 205640-90-0 |
| PubChem ID | 90470982 |
| InChI Key | IXODJSWYPSZUCI-IIIOAANCSA-N |
| Smiles | [H]N1[C@@H](CCC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CNC=N2)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(N)=O)NC1=O)[C@@H](C)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Orexin A (human, rat, mouse)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Orexin A (human, rat, mouse)
References for Orexin A (human, rat, mouse)
References are publications that support the biological activity of the product.
Kilduff and Peyron (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 23 359 PMID: 10906799
Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573 PMID: 9491897
Smart (1999) Orexins: a new family of neuropeptides. Br.J.Anaesth. 83 695 PMID: 10690128
Forte et al (2021) Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice. Nat.Commun. 12 6137 PMID: 34675233
Kaczmarek et al (2017) Chronic orexin-A (hypocretin-1) treatment of type 2 diabetic rats improves glucose control and beta-cell functions. J.Physiol.Pharmacol. 68 669 PMID: 29375041
If you know of a relevant reference for Orexin A (human, rat, mouse), please let us know.
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Keywords: Orexin A (human, rat, mouse), Orexin A (human, rat, mouse) supplier, Endogenous, agonists, OX1, OX2, Orexin, Non-Selective, Receptors, OrexinA, (human, rat, mouse), Non-selective, 1455, Tocris Bioscience
11 Citations for Orexin A (human, rat, mouse)
Citations are publications that use Tocris products. Selected citations for Orexin A (human, rat, mouse) include:
Forte et al (2021) Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice. Nat.Commun. 12 6137 PMID: 34675233
Khoo et al (2017) The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking. PLoS One 12 PMID: 28296947
Lungwitz et al (2012) Orexin-A induces anxiety-like behavior through interactions with glutamatergic receptors in the bed nucleus of the stria terminalis of rats. Physiol Behav 107 726 PMID: 22652097
Burdyga et al (2010) Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype. Am J Physiol Gastrointest Liver Physiol 299 G63 PMID: 20430875
Kim et al (2015) Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells. Brain Res 19 327 PMID: 26170736
Shu et al (2014) Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals. PLoS One 9 e95259 PMID: 24748172
Guo and Feng (2012) OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res 318 2004 PMID: 22652455
Moorman and Aston-Jones (2010) Orexin/hypocretin modulates response of ventral tegmental DA neurons to prefrontal activation: diurnal influences. J Neurosci 30 15585 PMID: 21084614
Kim and Han (2016) Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors. Exp Neurobiol 25 307 PMID: 28035181
Holland et al (2005) Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. Korean J Physiol Pharmacol 315 1380 PMID: 16160082
Gompf and Aston-Jones (2008) Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity. J Pharmacol Exp Ther 1224 43 PMID: 18614159
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ICV injection in rats.
By
Chris Holton on 05/31/2020
Assay Type: In Vivo
Species: Rat
ICV injection of orexin A at 20, 63 and 600 pmol in 2 uL aCSF in male Sprague Dawley rats under propofol anesthesia. Measurement of extracellular neuronal cell firing from the locus coeruleus. Clonidine 0.1 mg/kg i.p.
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