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Submit ReviewOrexin B (human)
Description: Endogenous agonist at OX1 and OX2
Purity: ≥95% (HPLC)
Biological Activity for Orexin B (human)
Orexin B (human) is an endogenous agonist at orexin receptors (Ki values are 420 and 36 nM for OX1 and OX2 receptors, respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Also neuroprotective for dopaminergic neurons in rat midbrain cultures.
Technical Data for Orexin B (human)
| M. Wt | 2899.36 |
| Formula | C123H212N44O35S |
| Sequence |
RSGPPGLQGRLQRLLQASGNHAAGILTM (Modifications: Met-28 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 205640-91-1 |
| PubChem ID | 90479794 |
| InChI Key | DHBREICAXZPFDD-WMQZXSDYSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Orexin B (human)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Orexin B (human)
References for Orexin B (human)
References are publications that support the biological activity of the product.
Kilduff and Peyron (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 23 359 PMID: 10906799
Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573 PMID: 9491897
Smart (1999) Orexins: a new family of neuropeptides. Br.J.Anaesth. 83 695 PMID: 10690128
Guerreiro et al (2015) The sleep-modulating peptide orexin-B protects midbrain DA neurons from degeneration, alone or in cooperation with nicotine. Mol.Pharmacol. 87 525 PMID: 25552485
If you know of a relevant reference for Orexin B (human), please let us know.
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Keywords: Orexin B (human), Orexin B (human) supplier, Endogenous, agonists, OX1, OX2, Orexin, Non-Selective, Receptors, OrexinB, (human), Non-selective, 1456, Tocris Bioscience
2 Citations for Orexin B (human)
Citations are publications that use Tocris products. Selected citations for Orexin B (human) include:
Guerreiro et al (2015) The sleep-modulating peptide orexin-B protects midbrain DA neurons from degeneration, alone or in cooperation with nicotine. Mol.Pharmacol. 87 525 PMID: 25552485
Malherbe et al (2009) Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor. Br.J.Pharmacol. 156 1326 PMID: 19751316
Do you know of a great paper that uses Orexin B (human) from Tocris? Please let us know.
Reviews for Orexin B (human)
Average Rating: 5 (Based on 1 Review.)
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A neuropeptide with multiple functions.
By
Samanta Grella on 02/17/2022
Assay Type: In Vivo
Species: Mouse
We used this drug to study its effect on brain proliferation. As shown in the attached image, we have found neural proliferation in the brain.
We always use freshly prepared drugs.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.