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Submit ReviewOrexin B (mouse)
Description: Endogenous agonist at OX1 and OX2
Purity: ≥95% (HPLC)
Biological Activity for Orexin B (mouse)
Orexin B (mouse) is an endogenous agonist at orexin receptors. May be involved in the regulation of feeding, sleep-wake cycle and other hypothalamic functions. Orexin B exerts excitatory effects on nigral dopaminergic neurons and alleviates motor symptoms in a Parkinson's disease mouse model.
Technical Data for Orexin B (mouse)
| M. Wt | 2936.43 |
| Formula | C126H215N45O34S |
| Sequence |
RPGPPGLQGRLQRLLQANGNHAAGILTM (Modification: Met-28 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 202801-92-1 |
| PubChem ID | 90479795 |
| InChI Key | RLVZFBVFVIDDPQ-GWQFQBPDSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Orexin B (mouse)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Orexin B (mouse)
References for Orexin B (mouse)
References are publications that support the biological activity of the product.
Kilduff and Peyron (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 23 359 PMID: 10906799
Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573 PMID: 9491897
Smart (1999) Orexins: a new family of neuropeptides. Br.J.Anaesth. 83 695 PMID: 10690128
Bian et al (2021) Orexin-B exerts excitatory effects on nigral dopaminergic neurons and alleviates motor disorders in MPTP parkinsonian mice. Neurosci.Lett. 765 136291 PMID: 34666119
If you know of a relevant reference for Orexin B (mouse), please let us know.
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Keywords: Orexin B (mouse), Orexin B (mouse) supplier, Endogenous, agonists, OX1, OX2, Orexin, Non-Selective, Receptors, OrexinB, (mouse), hypocretin, Non-selective, 1457, Tocris Bioscience
3 Citations for Orexin B (mouse)
Citations are publications that use Tocris products. Selected citations for Orexin B (mouse) include:
Guo and Feng (2012) OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res 318 2004 PMID: 22652455
Bian et al (2021) Orexin-B exerts excitatory effects on nigral dopaminergic neurons and alleviates motor disorders in MPTP parkinsonian mice Neurosci Lett 765 136291 PMID: 34666119
Holland et al (2005) Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. J Biol Chem 315 1380 PMID: 16160082
Do you know of a great paper that uses Orexin B (mouse) from Tocris? Please let us know.
Reviews for Orexin B (mouse)
Average Rating: 5 (Based on 1 Review.)
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High quality peptide.
By
Samanta Grella on 11/18/2022
Assay Type: In Vitro
Species: Mouse
This is the second Tocris peptide we have used in our study. The first one was from human origin (product #1456). Because a colleague suggested us to repeat the experiment with a peptide from mouse origin; we have chosen this product (Orexin B mouse). The results were amazing because the neuronal activation has increased at a level we were expecting to conduct the behavioural analysis. As shown in the attached graph, this compound stimulated neuronal activity at a hippocampus nuclei, as measured by immunoflurescence after compound delivery into the brain. We are very satisfied with the result and I recommed this Tocris product.
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.