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Description: Potent and selective inhibitor of the glial glycine transporter GlyT1b; active in vivo
Chemical Name: N-Methyl-N-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-glycine
Purity: ≥98% (HPLC)
Biological Activity for Org 24598
Org 24598 is a potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC50 < 4). Active in vivo.
Technical Data for Org 24598
| M. Wt | 367.36 |
| Formula | C19H20F3NO3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 372198-97-5 |
| PubChem ID | 5311285 |
| InChI Key | KZWQAWBTWNPFPW-QGZVFWFLSA-N |
| Smiles | CN(CC(O)=O)CC[C@@H](OC2=CC=C(C(F)(F)F)C=C2)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Org 24598
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.74 | 100 |
Preparing Stock Solutions for Org 24598
The following data is based on the product molecular weight 367.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.72 mL | 13.61 mL | 27.22 mL |
| 5 mM | 0.54 mL | 2.72 mL | 5.44 mL |
| 10 mM | 0.27 mL | 1.36 mL | 2.72 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets for Org 24598
References for Org 24598
References are publications that support the biological activity of the product.
Chue et al (2013) Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 19 1311 PMID: 23194655
Brown et al (2001) Discovery and SAR of org 24598-a selective glycine uptake inhibitor. Bioorg.Med.Chem.Lett. 11 2007 PMID: 11454468
Williams et al (2003) Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity. Anal. Biochem. 321 31 PMID: 12963052
If you know of a relevant reference for Org 24598, please let us know.
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Keywords: Org 24598, Org 24598 supplier, Org24598, glial, glycine, transporters, glyt1, inhibitors, inhibits, Glycine, Transporters, 4447, Tocris Bioscience
1 Citation for Org 24598
Citations are publications that use Tocris products. Selected citations for Org 24598 include:
Jaekwang et al (2020) The molecular mechanism of synaptic activity-induced astrocytic volume transient. J Physiol 598 4555-4572 PMID: 32706443
Do you know of a great paper that uses Org 24598 from Tocris? Please let us know.
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